Estimating population haplotype frequencies from pooled DNA samples using PHASE algorithm
نویسندگان
چکیده
منابع مشابه
Estimating population haplotype frequencies from pooled DNA samples using PHASE algorithm.
Recent studies show that the PHASE algorithm is a state-of-the-art method for population-based haplotyping from individually genotyped data. We present a modified version of PHASE for estimating population haplotype frequencies from pooled DNA data. The algorithm is compared with (i) a maximum likelihood estimation under the multinomial model and (ii) a deterministic greedy algorithm, on both s...
متن کاملEstimating Haplotype Frequencies from Genotypes of Pooled DNA
Estimating Haplotype Frequencies from Genotypes of Pooled DNA
متن کاملEstimating population haplotype frequencies from pooled SNP data using incomplete database information
MOTIVATION Information about haplotype structures gives a more detailed picture of genetic variation between individuals than single-locus analyses. Databases that contain the most frequent haplotypes of certain populations are developing rapidly (e.g. the HapMap database for single-nucleotide polymorphisms in humans). Utilization of such prior information about the prevailing haplotype structu...
متن کاملPoolHap: Inferring Haplotype Frequencies from Pooled Samples by Next Generation Sequencing
With the advance of next-generation sequencing (NGS) technologies, increasingly ambitious applications are becoming feasible. A particularly powerful one is the sequencing of polymorphic, pooled samples. The pool can be naturally occurring, as in the case of multiple pathogen strains in a blood sample, multiple types of cells in a cancerous tissue sample, or multiple isoforms of mRNA in a cell....
متن کاملHAPLOFREQ - Estimating Haplotype Frequencies E.ciently
A commonly used tool in disease association studies is the search for discrepancies between the haplotype distribution in the case and control populations. In order to find this discrepancy, the haplotypes frequency in each of the populations is estimated from the genotypes. We present a new method HAPLOFREQ to estimate haplotype frequencies over a short genomic region given the genotypes or ha...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genetics Research
سال: 2008
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s0016672308009877